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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1970 1
1974 1
1976 3
1977 2
1978 2
1979 1
1980 1
1982 1
1984 3
1985 1
1986 4
1987 1
1988 6
1989 3
1990 5
1991 6
1992 10
1993 12
1994 13
1995 11
1996 33
1997 15
1998 29
1999 36
2000 51
2001 56
2002 87
2003 90
2004 129
2005 123
2006 151
2007 141
2008 181
2009 239
2010 268
2011 341
2012 356
2013 369
2014 440
2015 513
2016 529
2017 548
2018 629
2019 756
2020 842
2021 1054
2022 1027
2023 1069
2024 467

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9,396 results

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Page 1
A dynamic perspective of RNAi library development.
Pan Q, van der Laan LJ, Janssen HL, Peppelenbosch MP. Pan Q, et al. Trends Biotechnol. 2012 Apr;30(4):206-15. doi: 10.1016/j.tibtech.2012.01.002. Epub 2012 Feb 1. Trends Biotechnol. 2012. PMID: 22305928 Review.
This article comparatively reviews the principles and applications of different RNAi libraries: from earlier synthetic to recent lentiviral RNAi libraries. The unique properties and limitations of each library will be important references for instigators to c …
This article comparatively reviews the principles and applications of different RNAi libraries: from earlier synthetic to recent lent …
Recent advances in DNA-encoded dynamic libraries.
Shi B, Zhou Y, Li X. Shi B, et al. RSC Chem Biol. 2022 Feb 17;3(4):407-419. doi: 10.1039/d2cb00007e. eCollection 2022 Apr 6. RSC Chem Biol. 2022. PMID: 35441147 Free PMC article. Review.
The DNA-encoded chemical library (DEL) has emerged as a powerful technology platform in drug discovery and is also gaining momentum in academic research. ...Recent innovations have combined DELs with other legacy and emerging techniques. Among them, the DNA-encoded dyna …
The DNA-encoded chemical library (DEL) has emerged as a powerful technology platform in drug discovery and is also gaining momentum i …
Dynamic Combinatorial Chemistry: A New Methodology Comes of Age.
Frei P, Hevey R, Ernst B. Frei P, et al. Chemistry. 2019 Jan 2;25(1):60-73. doi: 10.1002/chem.201803365. Epub 2018 Dec 11. Chemistry. 2019. PMID: 30204930 Review.
Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries for macromolecular targets. In the absence of an external stimulus, a dynamic library forms from reversibly reacting building …
Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries …
Dynamic combinatorial libraries of a dimercapto-pillar[5]arene.
Luo J, Guo Y, Li P, Sue AC, Cheng C. Luo J, et al. Chem Commun (Camb). 2022 Aug 2;58(62):8646-8649. doi: 10.1039/d2cc02752f. Chem Commun (Camb). 2022. PMID: 35822240
We report the synthesis and dynamic covalent chemistry (DCvC) of an A1/A2-dimercapto-functionalized pillar[5]arene (Di-SH-P5). The introduction of thiol moieties into this macrocyclic host makes it an effective building block for making a dynamic combinatorial li …
We report the synthesis and dynamic covalent chemistry (DCvC) of an A1/A2-dimercapto-functionalized pillar[5]arene (Di-SH-P5). The in …
Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective.
Saikia S, Bordoloi M. Saikia S, et al. Curr Drug Targets. 2019;20(5):501-521. doi: 10.2174/1389450119666181022153016. Curr Drug Targets. 2019. PMID: 30360733 Review.
Molecular docking is a process through which small molecules are docked into the macromolecular structures for scoring its complementary values at the binding sites. It is a vibrant research area with dynamic utility in structure-based drug-designing, lead optimization, bi …
Molecular docking is a process through which small molecules are docked into the macromolecular structures for scoring its complementary val …
DNA-Encoded Dynamic Chemical Library and Its Applications in Ligand Discovery.
Zhou Y, Li C, Peng J, Xie L, Meng L, Li Q, Zhang J, Li XD, Li X, Huang X, Li X. Zhou Y, et al. J Am Chem Soc. 2018 Nov 21;140(46):15859-15867. doi: 10.1021/jacs.8b09277. Epub 2018 Nov 9. J Am Chem Soc. 2018. PMID: 30412395
Dynamic combinatorial library (DCL) has emerged as an efficient tool for ligand discovery and become an important discovery modality in biomedical research. However, the applications of DCLs have been significantly hampered by low library diversity and limite …
Dynamic combinatorial library (DCL) has emerged as an efficient tool for ligand discovery and become an important discovery mo …
Simultaneous Formation of a Fully Organic Triply Dynamic Combinatorial Library.
Drożdż W, Walczak A, Stefankiewicz AR. Drożdż W, et al. Org Lett. 2021 May 7;23(9):3641-3645. doi: 10.1021/acs.orglett.1c01042. Epub 2021 Apr 27. Org Lett. 2021. PMID: 33904751 Free PMC article.
Here we report the simultaneous formation of doubly and triply dynamic libraries as a result of exchange reactions between functionalized organic building blocks. A combination of three different reversible covalent linkages involving a boronate ester transesterific …
Here we report the simultaneous formation of doubly and triply dynamic libraries as a result of exchange reactions between fun …
Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library.
Zhou Y, Shen W, Peng J, Deng Y, Li X. Zhou Y, et al. Bioorg Med Chem. 2021 Sep 1;45:116328. doi: 10.1016/j.bmc.2021.116328. Epub 2021 Jul 25. Bioorg Med Chem. 2021. PMID: 34364223
DNA-encoded chemical library (DEL) has emerged to be a powerful ligand screening technology in drug discovery. Recently, we reported a DNA-encoded dynamic library (DEDL) approach that combines the principle of traditional dynamic combinatorial libra …
DNA-encoded chemical library (DEL) has emerged to be a powerful ligand screening technology in drug discovery. Recently, we reported …
SwiftLib: rapid degenerate-codon-library optimization through dynamic programming.
Jacobs TM, Yumerefendi H, Kuhlman B, Leaver-Fay A. Jacobs TM, et al. Nucleic Acids Res. 2015 Mar 11;43(5):e34. doi: 10.1093/nar/gku1323. Epub 2014 Dec 24. Nucleic Acids Res. 2015. PMID: 25539925 Free PMC article.
Degenerate codon (DC) libraries efficiently address the experimental library-size limitations of directed evolution by focusing diversity toward the positions and toward the amino acids (AAs) that are most likely to generate hits; however, manually constructing DC …
Degenerate codon (DC) libraries efficiently address the experimental library-size limitations of directed evolution by focusin …
Fuel-Driven Dynamic Combinatorial Libraries.
Kriebisch CME, Bergmann AM, Boekhoven J. Kriebisch CME, et al. J Am Chem Soc. 2021 May 26;143(20):7719-7725. doi: 10.1021/jacs.1c01616. Epub 2021 May 12. J Am Chem Soc. 2021. PMID: 33978418
Interestingly, we found that the dynamics of the library's components were dominated by transacylation, which is an equilibrium reaction. In contrast, the library's dynamics were dictated by fuel-driven activation, which is a nonequilibri …
Interestingly, we found that the dynamics of the library's components were dominated by transacylation, which is an equ …
9,396 results